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Given the intractable pediatric obesity epidemic and associated rise in type 2 diabetes in youth, made worse by the COVID-19 pandemic related shutdowns and disruptions in opportunities for exercise and play in youth, this new class of medications will certainly benefit children with morbid obesity and type 2 diabetes

doi:10.2147/jir.s470520

Less common but notable side effects include headaches , muscle pain , fatigue , anxiety , sleep disturbances , injection site reactions , and body aches

Basal metabolic rate drops by approximately 200-250 calories daily as lean muscle mass decreases

95% CI, 1.28-2.6)