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Your semaglutide injection must stay refrigerated between 36F and 46Fthe temperature range of a standard household refrigerator

Although the substitution of C236 3.39b appeared to have minimal effects on GLP-1 pharmacology, the mutation of the conserved C226 3.29b in two studies led to either no detectable activity or a 25-fold reduction in GLP-1 affinity with 38-fold lower potency

This cardiovascular distinction is clinically significant

doi: 10.1016/0014-5793(81)80772-7 [DOI] [PubMed] [Google Scholar] 87