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Pending further scientific evidence, if the quantitative measure defining significant weight loss is at least 5% compared to baseline, this value could be considered clinically suggestive of weight regain and represent an indication for cyclic resumption of pharmacological therapy at the maximum tolerated dose

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In SURMOUNT-1, the most common treatment-emergent adverse events were gastrointestinal: nausea (24.6-33.3% across doses vs 9.5% placebo), diarrhea (18.7-21.2%), vomiting (5.7-12.2%), and constipation (5.8-11.5%)
