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Dr Koul noted that in supervised settings, most side effects are manageable and severe complications remain uncommon

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Prices are expected to level off as more companies pump more GLP-1 drugs into the market

While generally considered safe, semaglutide may be less effective for patients with MASH who dont also have obesity or diabetes, poses specific risks for older adults (like muscle loss and side effects), and isnt approved for children or teens or for those navigating severe complications like cirrhosis

An initial analysis said most of that loss came from fat rather than muscle, with lean mass contributing only a small proportion of total weight. Boehringer Ingelheim also reported a statistically significant reduction in waist circumference versus placebo after 76 weeks, calling it a marker closely linked to visceral fat and cardiometabolic risk