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They tend to work best when combined with these lifestyle habits
GLP-1/GIP is a peptide that functions as a receptor agonist and acts on ghrelin receptors in the brain
2 Metabolic models Scientists evaluate glucose tolerance, insulin sensitivity, and pancreatic beta cell function in type 2 diabetes mouse models

Novelty and new experiences stimulate dopamine release
DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

Optimal outcomes require integration with dietary modification emphasizing whole foods and reduced processed carbohydrate intake, regular physical activity including both aerobic and resistance training, and management of other cardiovascular risk factors