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Obesity engenders an environment whereby CD8+ TILs are ineffective and hyporesponsive, resulting in rapid acceleration of tumor growth 68

Overall, although a net beneficial effect on several cardiometabolic variables was maintained 1 year after semaglutide withdrawal, greater benefits were seen during the treatment period, supporting the need for continued treatment

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This dual approach may result in a more pronounced reduction in appetite, aiding individuals in adhering to caloric restrictions and making healthier food choices