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Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK

The best characterized activators include temperatures greater than 43 C, low pH, capsaicin, and allyl isothiocyanate [80]

Whether the addition of glucagon receptor agonism in retatrutide meaningfully alters the overall GI side effect burden compared with approved agents remains uncertain