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Ozempic and other GLP-1 receptor agonists can increase insulin secretion, suppress glucagon release, slow digestion, and more

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Methods In accordance with the PRISMA guidelines, we systematically searched PubMed, Embase, Cochrane Library, Web of Science, Scopus, and LILACS for randomized controlled trials and observational studies published between 2000 and 2025

Aims/hypothesis Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glycaemic management in both mice and humans

GLP-1 weight loss therapy is now accessible without insurance coverage through compounded medications priced from $129 monthly at PlexusDx, eliminating the need for prior authorizations or membership commitments

Although dedicated trials of GLP-1RAs in AITD are lacking, preliminary reports suggest potential impacton thyroid volume, thyroid function, and autoimmune activity