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Description
Osteoarthitis of leptin-deficient ob/ob mice in response to biomechanical loading in micro-CT

No evidence of cardiac, hepatic, or renal toxicity, changes in serum lipids, or clinically relevant changes in laboratory parameters, vital signs, electrocardiograms, or abnormal findings upon physical examinations have been observed
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While on the reduced dose frequency, patients on average experienced a slight additional loss of weight
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