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Many patients experience improvements in insulin sensitivity, reversal of prediabetes, and overall metabolic flexibility

[DOI] [PubMed] [Google Scholar] 63.Zelniker T.A., Wiviott S.D., Raz I., Im K., Goodrich E.L., Furtado R.H.M., Bonaca M.P., Mosenzon O., Kato E.T., Cahn A., et al

260 GLP-1 downregulated Na+/H+ exchanger isoform 3 in the renal proximal tubule of rats, suggesting that GLP-1 could be used to treat hypertension and sodium retention disorders

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Treatment is typically limited to a maximum of 2 years
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