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As a result, GLP-1 receptor agonists (GLP-1RA) were developed

L., West, A

Several large clinical trials have demonstrated that GLP-1 receptor agonists can reduce the risk of cardiovascular events, such as heart attacks and strokes, in people with type 2 diabetes who are at high risk for heart disease

After 48 weeks, half of the participants using GLP-1 lost 20% of their body weight and nearly a third lost 25%

WHAT IT DOES (mechanistically) Inhibits mitochondrial Complex I activates AMPK suppresses hepatic gluconeogenesis