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Krug I, Dang AB, Portingale J, Li Y, Won YQ

The indirect effects, mediated through reductions in HbA1c and body weight, appeared to explain 45.9% [95% CI 20.771.0%] of the decrease in UACR associated with tirzepatide relative to the pooled comparator and driven primarily by improved glycemic control, with no statistically significant role for weight reduction

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Her HbA1c was 6% and her fasting glucose was 5.3 mmol/l

For example, a major study in the New England Journal of Medicine found that weekly injectable semaglutide helped adults lose nearly 15% of their body weight over 68 weeks

Participants were aged 54.7 years, on average