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N Engl J Med 2021;385: 896-907

Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies

Nishizawa M, Nakabayashi H, Uchida K, Nakagawa A, Niijima A

Insurance coverage represents another major barrier to broader adoption

Patch: $99 to start, then $149 per month

In order to prevent degradation by DPP-4, scientists swapped the alanine at the inactivation site with a glycine
