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BMJ 344:d7771

29 , 56 In the SUSTAIN trials, semaglutide use has been shown to lower HbA1c, reduce BW and lower blood pressure when compared to placebo

42% of former GLP-1 users said they would be very likely to resume treatment if cost and side effects were reduced

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Materials and methods This study was designed following the framework delineated by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [17] with rigorous attention given to registering the study protocol in the International Prospective Register for Systematic Reviews (PROSPERO) (registration code: CRD42023466256)

Preclinical Evidence Animal studies demonstrate reproductive toxicity, including skeletal and visceral abnormalities, dose-dependent growth restriction, and embryonic death