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Introduction: from Adverse Events to Beneficial Events The mighty adverse event (AE) case report form (CRF) had its humble beginning in 1938 when

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Its peptide-based structure offers prolonged receptor interaction, making it useful for studies involving glucose signaling, satiety regulation, and incretin-related mechanisms

Aims/hypothesis A protective role of sodiumglucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP1-ra) in the development of diabetic retinopathy and diabetic macular oedema has been described in some recent studies, which may extend beyond glycaemic control