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GLP-1s may help with OA by: Reducing overall inflammation Protecting cartilage in your joints Helping people lose weight takes pressure off the knees and hips Making walking and movement easier over time Studies found that GLP-1 and SGLT2 medicines may lower the risk of needing a knee replacement (for OA), though results varied

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The onset of GLP-1RA treatment can lead to Pso flare-ups in some patients, which indicates differences in how individuals immune systems respond to the medication [58,66]

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