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[DOI] [PMC free article] [PubMed] [Google Scholar] 278.Reimann F., Gribble F.M

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While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives

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Its worth noting that most treatment discontinuations occurred during the rapid dose-escalation phase, suggesting that a more gradual dose-escalation strategy could potentially mitigate these issues

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