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Consequently, further investigation is required to contextualize findings generated from oral GLP-1 agonists

(Photo by Niki Kelly/Indiana Capital Chronicle) Indiana lawmakers are weighing new guardrails around drug compounding amid warnings that patients are receiving powerful prescription treatments in settings that operate largely outside state oversight
However, the significance of this finding in humans is still unclear, and further research is needed to determine the potential risks in humans

Diabetes Obesity Metab 26(5):17991807 Jensen L, et al (2017) Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species

Once daily injectable liraglutide (marketed as Victoza for T2DM and Saxenda for obesity) and once weekly injectable semaglutide (marketed as Ozempic for T2DM and Wegovy for obesity) are two additional GLP-1 analogues, sharing 97% and 94% amino acid homology to GLP-1, respectively [ Figure 2 , Table 1 ]
This is why the larger phase 3 and cardiovascular outcomes trials are essential
