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Which innovation will have the biggest impact over the next decade: GLP-1s, Triple Agonists, AI-driven care, or Cell Therapy

Physiologic release of incretins also causes postprandial blood glucose reduction by reducing circulating glycogen and increasing insulin

For weight management, NICE technology appraisals TA875 (semaglutide) and TA664 (liraglutide) recommend these medicines for people meeting certain criteria within specialist weight management services

How Do GLP-1s Work

Without concurrent attention to muscle maintenance, bone health, and long-term lifestyle change, patients risk losing critical lean mass and regaining weight as mostly fat, which can ultimately worsen joint pain, weaken bone density, and compromise recovery

Mark Pimentel, MD, Executive Director of the Medically Associated Science and Technology Program at Cedars-Sinai, and a leading expert on microbial overgrowths, puts it this way: Any factor that slows down the speed of flow [of food] through the small intestine has the potential to cause [bacterial] overgrowth. This is important for patients assessing their SIBO risk, because studies suggest GLP-1 signaling can inhibit aspects of the Migrating Motor Complex (MMC)
