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Another consideration for GLP-1/GIP/GCG agonists is their potential negative impact on lean mass [32]
However, blood sugar monitoring should be increased after stopping, as glucose control will deteriorate

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Metabolic stress promotes the formation of advanced glycation end products (AGEs), which activate inflammatory signaling through the receptor for advanced glycation end products (RAGE) [8]

Some case reports involved MCAS patients who took the standard dose to lose weight and experienced other kinds of relief
