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GLP-1 has been shown to have insulin-independent effects on hepatic glucose uptake [87]

Wegovy and Ozempic are 2 treatments with exactly the same active ingredient , semaglutide

reported that in hippocampal slices in seizure-induced SpragueDawley rats, exendin939, a GLP-1 receptor antagonist, significantly decreased GABA A Rbeta2/3 expression and increased GluR expression (ie, GluA14, GluN1, GluN2A, GluN2B).Reference Wen, Wu, Xie, Dan, Zhan and Shi 48 When samples were treated with GLP-1 RA, there was increased GABA A R2/3 expression and decreased GluR expression.Reference Wen, Wu, Xie, Dan, Zhan and Shi 48 Overall, the included studies support that GLP-1 RAs may be associated with increased glutamatergic receptor activity via multiple cellular and molecular mechanisms (Figure 2)

At the end of the study period, 70.0% and 61.1% of women in the elinzanetant and placebo arms, respectively, experienced at least one treatment-emergent AE (TEAE)