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Based on the strength of evidence and safety boundaries, a more rational clinical positioning is to reserve GLP-1RAs as an individualized tool for intensive metabolic optimization prior to ART in refractory PCOS individuals with high BMI and prior weight-loss failure

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The SUSTAIN-6 trial showed a significant reduction in major adverse cardiovascular events (MACE), including non-fatal myocardial infarction and non-fatal stroke, specifically in patients with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors