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A secondary analysis of clinical trial data found that up to 40% of weight lost on semaglutide can be lean mass -- muscle and bone -- rather than fat, particularly in women and older adults

Other weight loss medications to consider Numerous medications are on the market for weight loss (Editors note: See FDA-Approved Medications to Treat Obesity table below)

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The weight-loss drugs being tested in 2025: will they beat ozempic

This review explores factors that may contribute to accelerated muscle loss among higher-risk patient populations and describes tailored interventions to reduce the risk of accelerated sarcopenia and frailty