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Weight loss not only improves glycemic control but also reduces ectopic adipose tissue depots, such as perivascular and epicardial fat, that exert direct deleterious effects on the vascular endothelium [124]

Psoriatic arthritis is the major systemic manifestation, affecting up to 30% of patients

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These include conjugation with sulfation and glucuronidation, resulting in the formation of curcumin sulfate and curcumin glucuronide, respectively (Figure 2)