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The current study did not assess glycemic outcomes longitudinally at each dose and hence it is not possible to assess if the dose escalation patterns were optimal for glycemic outcomes

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[DOI] [PubMed] [Google Scholar] 6.Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, et al

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This evolutionary response safeguards energy reserves in the event of food shortage (metabolic adaptation) [12, 31]

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Together these data suggest a role for -cell GLP-1 production in the adaptation to metabolic disease

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New patients typically start at the 2.5 mg starting dose by default, which can be low for individuals who have been on semaglutide in the past No live visit

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