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This technique involves alternating acylation with bromoacetic acid and N,N-diisopropyl carbodiimide (DIC), along with nucleophilic displacement reactions of the bromide using primary amines (Scheme )

Mastering Injection Site Rotation Systematic site rotation prevents the tissue damage and scar formation that causes injection sites to become progressively more uncomfortable over time

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Lancet (2015) 385:206776
