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Yes, the glucagon receptor activation in retatrutide may increase resting energy expenditure and promote thermogenesis, meaning the body burns more calories at rest compared to GLP-1-only medications like semaglutide

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54.9% The lean mass preserved additionally in participants receiving apitegromab alongside tirzepatide in the phase 2 EMBRAZE trial, compared with tirzepatide and placebo, while achieving similar overall weight loss