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Unlike other current weight loss medications on the market, it simultaneously activates three key hormone receptors: GLP-1 receptor GIP receptor Glucagon receptor By targeting all three, Retatrutide delivers a comprehensive approach to weight management by: Suppressing appetite and slowing digestion Enhancing metabolic activity Regulating blood sugar levels Promoting fat breakdown In comparison to other weight loss drugs like Wegovy and Ozempic ( Semaglutide ) that only target GLP-1, while other options like Zepbound and Mounjaro ( Tirzepatide ) activate both GLP-1 and GIP

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Development 125, 18031813

doi: 10.1097/MED.0000000000000569

Gastroenterology 167 (4), 689703

doi: 10.1016/j.jtcme.2016.11.007