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Six studies assessed all three eligible tirzepatide maintenance doses (5, 10 and 15 mg once-weekly), while one study included two arms with a maintenance dose of 15 mg but with two different dose-escalation regimens [18]

The risk magnitude rises with the severity of liver disease in NAFLD, particularly at higher fibrosis stages [42]

Utilizing the concept of elevating GLP-1 concentrations, DPP-4 inhibitors as oral agents and synthetic injectable, DPP-4 resistant GLP-1 receptor agonists (GLP-1RA) were introduced as treatment options for T2D therapy (3136)

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