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Several factors influence DPP-4 activity: Genetics: Polymorphisms in the DPP4 gene affect enzyme expression and activity Metabolic status: Insulin resistance correlates with elevated DPP-4 activity Inflammation: Chronic inflammation increases DPP-4 expression Age: DPP-4 activity tends to increase with aging Diet composition: Certain dietary patterns modulate DPP-4 expression This variability explains why some people maintain better natural GLP-1 levels than others, even with similar L-cell activation strategies

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Incorporate EMS or weight training to preserve tone

Despite normalization of liver injury indices is an independent predictor of fibrosis improvement in patients with NASH [65], for several drugs this improvement is not associated with a significant histological and prognostic benefit [7,68]

Endocrinology 1986, 119, 14671475

Castelli MC, Wong DF, Friedman K, Riley MG