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Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

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Methods Blood was drawn from 24 subjects (14 male, 10 female, age: 50.77.36years, BMI: 26.643.38kg/m2, GHbA1c: 7.000.74%) with drug-nave T2D at 0 and 120min following a standard mixed meal for the measurements of active GLP-1, NO and NOS

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Clinical Trial Registration Number NCT03061214.

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