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We replaced liraglutide with FGF21 and assessed the impact of further leptin reduction

41 This finding was consistent with oral semaglutide, with mild-to-moderate gastrointestinal adverse events being the most commonly reported events in clinical trials

The article on GLP-1 medications and inflammation covers the underlying biology in more detail for readers who want to go deeper on this

Avoid strenuous exercise immediately after eating while your body adjusts to the medication

Data availability All data and materials not already presented in this work may be made available upon request

The Institute for Clinical and Economic Reviews (ICERs) Tirzepatide for Type 2 Diabetes Final Report stated tirzepatide shows impressive impact on glucose lowering and glycemic control