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On the other hand, insulin promotes pancreatic cancer initiation and sustains PDA development by eliciting tumorigenic inflammation, regulating lipid and glucose metabolic reprogram, overcoming apoptosis through the crosstalk with IGF-1, stimulating cancer metastasis, and activating tumor microenvironment formation (inflammation, fibrosis, and angiogenesis)
Mice were housed three per cage in a room with controlled temperature, humidity, and alternating light and dark cycle (12:12 h light/dark cycle)
doi: 10.1016/S0140-6736(19)31149-3 [DOI] [PubMed] [Google Scholar] 43
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575 ZhouH.YangJ.XinT.LiD.GuoJ.HuS.et al (2014)
doi: 10.1038/s41598-020-73668-y
