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I have lowered my A1C several points, and Im down a shirt size

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[6] found a progressively increased risk of gall bladder and biliary disorders with higher doses and longer duration of administration of GLP-1RAs

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Thus, for a number of them, even if they are good substrates in vitro , other clearance pathways may be more important in vivo or, if they are cleaved by DPP-4, removal of the N-terminal dipeptide may have no effect upon their biological activity
