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They work by inhibiting glucagon secretion, delaying gastric emptying, and suppressing appetite, which helps regulate blood sugar levels and promote weight loss.However, concerns have been raised in recent years over whether these medications reduce weight mainly via muscle mass loss, which could lead to physical frailty or sarcopenia.Led by assistant professor

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Current and pipeline incretin portfolio: GLP1, GLP1/GIP, GLP1/GRA, and amylincontaining combinations across SC and oral routes, with several Phase 23 agents aiming for ~2025% weight loss and cardiometabolic indications.