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Results: GLP-1 RA use was not associated with an increased overall risk of GI cancers (HR 0.81: 95% CI: 0.680.96)

however, no safe and efficacious pharmacotherapy is approved for obesity so far

All original arms are eligible to preserve blinding

Tesamorelin is a synthetic growth hormone-releasing hormone analogue used in some countries for HIV-associated lipodystrophy, whilst retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) currently in Phase 3 trials

GLP-1RA can enhance renal function and renal blood flow, facilitate the recovery of vascular endothelial function, reduce urinary protein, and play a protective role in the kidney

doi: 10.1093/cvr/cvac013 62 MarguliesKBHernandezAFRedfieldMMGivertzMMOliveiraGHColeRet al