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This biomarker-based approach complements stratification by clinical phenotype

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Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116

[97] observed a significant reduction in APRI in patients treated with liraglutide, similar to those treated with pioglitazone

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