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At equivalent doses, tirzepatide produced greater HbA1c reductions and greater weight loss than semaglutide when added to metformin

One important thing to keep in mind: people in these studies were also making changes to how they were eating and moving

metformin 1000 mg BID led to conflicting results on hyperandrogenism

Less ideal candidates: BMI 2730 (mild overweight) where the efficacy advantage may not justify the tolerability trade-off
But there is still an increasing amount of interest for it, therefore, overwhelming their ability to produce enough supplies

The lawsuit claims the manufacturer failed to adequately warn about the risk of serious gastrointestinal side effects
