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Redox Biol 1:7079 Knudsen ST, Bek T, Poulsen PL, Hove MN, Rehling M, Mogensen CE (2002) Macular edema reflects generalized vascular hyperpermeability in type 2 diabetic patients with retinopathy

Variability Across Study Designs Safety signals in published studies vary due to differences in: species used (rodents vs other models) dosing magnitude route of administration model type (injury-induced vs healthy tissue) study duration This variability limits the ability to draw broad conclusions

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Furthermore, a blinded immunohistochemical study of skin biopsies revealed a significant increase in the number of mast cells in the dermis of fibromyalgia patients compared to healthy subjects (103)