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24.2% weight loss at 48 weeks (Phase 2)

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First, the stepwise increase in weight loss as additional receptor mechanisms are added (GLP-1 only to GLP-1+GIP to GLP-1+GIP+glucagon) is consistent with the additive-mechanism hypothesis that underpinned the retatrutide program

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This dual approach could theoretically offer a more complete strategy for improving metabolic health, especially for individuals facing significant challenges with obesity, insulin resistance, or age-related metabolic decline