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Five of these trials have shown superiority in reducing MACE compared to placebo, while all have confirmed the cardiovascular safety of GLP-1 RAs (76)
In summary, current evidence clearly shows direct cardioprotective effects of GLP-1 and GLP-1RAs in preclinical models of heart failure (Figure 2)
PMID: 19403868
They contain sorbitol, a natural sugar alcohol that pulls water into the colon through osmotic action
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