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A random effects model was selected to perform the meta-analyses, results were expressed as weighted mean differences for continuous outcomes and relative risks for dichotomous outcomes, both with 95% confidence intervals, and with I2 values and P values as markers of heterogeneity

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Includes MHRA Yellow Card reporting guidance.

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Designed with daily routines in mind, the oral spray format may be preferred by some individuals when discussing non-injectable administration options with their healthcare provider