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In recent years, the interest in kidney hypoxia as a driver of DKD has been revived owing to the development of techniques that allow the study of kidney oxygen availability

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In addition, it has been reported that liraglutide ameliorates the lipotoxic, inflammatory effects of high-calorie diet feeding in vivo and palmitic acid treatment in vitro via inhibition of the mTORC1 signaling pathway [107]

The study found that infants whose mother had pre-gestational type 2 diabetes had a substantially higher prevalence of MCMs, including cardiac malformations, compared with infants in the general population

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The safety profile was similar to that described in other clinical trials [56]