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However, no clinical trials of retatrutide specifically in women with PCOS have been published, so any benefit remains unproven

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Auge M, Menahem B, Savey V, Lee Bion A, Alves A

Reported side effects Nausea and reduced appetite the most commonly reported effects in the research literature, usually easing as the dose is titrated slowly

Fatigue and dizziness may appear within the first few days and usually resolve within one to two weeks as your body stabilizes to the medication's mechanism of action

Does Rybelsus build up to higher doses eventually

These gastrointestinal symptoms correlate with dose escalation and typically resolve by week 12 once the body adapts to the medication