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Patients with a history of depression, anxiety disorders, bipolar disorder, or previous suicidal thoughts warrant closer monitoring during GLP-1 treatment, as these pre-existing conditions represent the most significant risk factors for suicidal ideation

Ultimately, these drugs significantly suppress hunger, and still require a calorie deficit to work

(2013) expanded this evidence base by systematically evaluating the effects of Ex4 on locomotor activity, NAc dopamine release, and reward-associated learning induced by both cocaine and amphetamine

10.1186/s12987-025-00652-x [DOI] [PMC free article] [PubMed] [Google Scholar] 31.Heckel B (2024) Idiopathic intracranial hypertension after abrupt cessation of medication: A case report of abrupt Glucagon-like peptide-1 (GLP-1) receptor agonist cessation and review of the literature