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This is why doctor-led weight management is important

3.1 Clinical trial landscape: observations on effect size and heterogeneity Currently, RCTs of GLP-1RAs in PCOS are generally characterized by small sample sizes, single-center designs, and relatively short follow-up periods

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Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues

Herman et al

* Liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound) are also FDA-approved for weight loss and weight management in patients with obesity without diabetes