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doi: 10.1001/jama.2021.3224

I expect that there will be at least one arm of the phase 3 trials Lilly will run, and I suspect they may also try a 12mg arm and probably a 6mg arm as they tend to aim for 3 approved doses for weight loss indications

Reflecting this difficulty Novartis and Probiodrug had to abandon some of their early drug candidates because they proved unsafe and too toxic (Cordes)

Indeed, the potential promise of GLP-1(2836) as a synthetic peptide that enables GLP-1Rindependent, MTP-dependent, sAC-mediated cytoprotective cAMP signaling, with no effect on HR, is worthy of further exploration

The role of GLP-1 in mediating the function of GCs and the oocyte development in PCOS was investigated by Sun Z et al

FDA-approved labeling provides specific escalation schedules that should be followed carefully, with consideration for even slower titration in high-risk patients