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In adipocytes, caveolin-1 plays a role in the insulin transduction pathway by modulating the activity of down-stream signaling proteins including Akt (94), raising the possibility that DPP-4 may be able to influence adipocyte insulin sensitivity by modulating the activity of caveolin-1 (Figure 3)

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Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials

3d shows that Trp 33 is conserved in human and monkey GLP-1R whereas mouse, rat and pig have a serine residue in the corresponding position

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