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Functional brain imaging techniques, such as functional magnetic resonance imaging (fMRI) and fluoro-deoxy-glucose positron emission tomography (FDG-PET), have shown that the orbitofrontal cortex (OFC) is activated when individuals consume food until they feel full

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Furthermore, GPR40 also shows synergism with GPR119, mediating a more than additive GLP-1 response to triglycerides in the large intestine (263)

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