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The amount should be individualised based on factors such as age, weight, and activity level, with guidance from a healthcare professional or dietitian

Some individuals also experience gradual weight loss during this period, averaging 23 kg over several months

Removal of this protecting group requires high concentrations of TFA, often resulting in degradation impurities and lower product yield and purity

This is greater than the 1.2% and 1.4% drops seen in Rybelsus patients

Cell viability assay Cell viability was assessed using the MTS assay (CellTiter 96 AQueous One Solution Cell Proliferation Assay, Promega) according to the manufacturers instructions

For detailed storage guidelines , including stability during temporary temperature excursions, see our complete storage guide